- French Institute for Public Health Surveillance (Institut de Veille Sanitaire; InVS), Ile-de-France and Champagne-Ardenne, France
- Institut Pasteur, National Reference Center for Meningococci, Paris, France
- French Institute for Public Health Surveillance (Institut de Veille Sanitaire; InVS), Saint Maurice, France
n April 2012, a cluster of two cases of meningococcal disease caused by rifampicin-resistant C meningococci was reported in the Champagne-Ardenne region, France. The two cases occurred in a student population living in the same town but studying at different schools. Bacteriological and epidemiological investigations of cases have shown that the isolates of both cases were non-differentiable.
…In April 2012, at an approximate interval of 10 days, we observed two cases of IMD caused by rifampicin-resistant C meningococcus in students in the Champagne-Ardenne region. Failure of chemoprophylaxis, due to antibiotic resistance, could lead to the occurrence of secondary cases [13–15]. Therefore, the use of rifampicin in chemoprophylaxis against already resistant bacteria creates a positive selection for resistant strains that may then provoke secondary cases. The detection of the cluster of two cases with non-differentiable isolates of rifampicin-resistant C meningococci suggests the possible carriage and circulation of the ST-11 strain in the student population of the Champagne-Ardenne region. …